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Also affects procoagulant proteins, adhesive factors and the metabolism of arachidonic acid within the endothelial cell. The National Organization for Rare Disorders (NORD) is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD.

Once it binds, it is incapable of releasing until the body eliminates the enzyme from the body. Detractors raise questions about the risks of sepsis and gastrointestinal hemorrhage with glucocorticoid therapy.

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